Extrachromosomal rDNA circle

Extrachromosomal rDNA circles (ERC) are self replicating circles of ribosomal DNA found in some strains of yeast and thought to contribute to their aging.[1] [2] [3]

The ERC accumulate in the mother cell during the budding process.[3]

They are a type of Extrachromosomal Circular DNA (eccDNA),[4] a type of Extrachromosomal DNA.

See also

References

  1. ^ Sinclair DA, Guarente L (1997). Extrachromosomal rDNA circles--a cause of aging in yeast.. 91. pp. 1033–42. doi:10.1016/S0092-8674(00)80493-6. PMID 9428525. 
  2. ^ "Molecular Mechanisms of Yeast Lifespan Extension by Calorie Restriction". Dec 2007. http://www.bsra.org.uk/e-lifespan/frontline/molecular-mechanisms-yeast-lifespan-extension-calorie-restriction. 
  3. ^ a b Nyström (2007). "A Bacterial Kind of Aging". http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.0030224. 
  4. ^ Cohen at al. (2003). Extrachromosomal Circular DNA of Tandemly Repeated Genomic Sequences in Drosophila. http://genome.cshlp.org/content/13/6a/1133.long.